{"id":29431,"date":"2017-08-01T14:24:18","date_gmt":"2017-08-01T14:24:18","guid":{"rendered":"https:\/\/www.edristi.in\/?p=29431"},"modified":"2017-08-01T14:24:18","modified_gmt":"2017-08-01T14:24:18","slug":"human-antibodies-produced-lab-first-time","status":"publish","type":"post","link":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/human-antibodies-produced-lab-first-time\/","title":{"rendered":"Human antibodies produced in lab for first time"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Question:- Who led the research which has succeeded in producing human antibodies in the laboratory?<\/strong><br \/>\n(a) Facundo Batista<br \/>\n(b) Elizabeth Blackburn<br \/>\n(c) Rita Levi-Montalcini<br \/>\n(d) Ralph M. Steinman<br \/>\n<strong>Answer :- (a)<br \/>\nRelated facts:- <\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>According to reports dated July 25, 2017, Researchers, led by Facundo Batista from the Francis Crick Institute in the UK, produced specific human antibodies in the laboratory by treating patient-derived B cells with tiny nanoparticles coated with both CpG oligonucleotides and an antigen.<\/li>\n<li>With this technique, CpG oligonucleotides are only internalized into B cells that recognise the specific antigen, and these cells are therefore the only ones in which TLR9 is activated to induce their proliferation and development into antibody-secreting plasma cells.<\/li>\n<li>The team successfully demonstrated their approach using various bacterial and viral antigens, including the tetanus toxoid and proteins from several strains of influenza A.<\/li>\n<li>In each case, the researchers were able to produce specific, high-affinity antibodies in just a few days. Some of the anti-influenza antibodies generated by the technique recognised multiple strains of the virus and were able to neutralise its ability to infect cells.<\/li>\n<li>The procedure does not depend on the donors having been previously exposed to any of these antigens through vaccination or infection.<\/li>\n<li>This method will allow the production of these antibodies within a shorter time frame in vitro and without the need for vaccination or blood\/serum donation from recently infected or vaccinated individuals.<\/li>\n<li>This method offers the potential to accelerate the development of new vaccines by allowing the efficient evaluation of candidate target antigens.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>Reference:<\/strong><br \/>\n<a href=\"http:\/\/jem.rupress.org\/content\/early\/2017\/07\/26\/jem.20170633\" target=\"_blank\" rel=\"noopener\">http:\/\/jem.rupress.org\/content\/early\/2017\/07\/26\/jem.20170633<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Question:- Who led the research which has succeeded in producing human antibodies in the laboratory? (a) Facundo Batista (b) Elizabeth Blackburn (c) Rita Levi-Montalcini (d) Ralph M. Steinman Answer :- (a) Related facts:- According to reports dated July 25, 2017, Researchers, led by Facundo Batista from the Francis Crick Institute in the UK, produced specific [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":29432,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1123],"tags":[3119],"class_list":["post-29431","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-snes","tag-science-en"],"_links":{"self":[{"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/posts\/29431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/comments?post=29431"}],"version-history":[{"count":0,"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/posts\/29431\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/media\/29432"}],"wp:attachment":[{"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/media?parent=29431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/categories?post=29431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.edristi.in\/hi\/%e0%a4%b9%e0%a5%8b%e0%a4%ae\/wp-json\/wp\/v2\/tags?post=29431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}